反应详情

Intermediate 6a (212 mg, 1.04 mmol) was dissolved in ethanol (20 mL) then hydrogenated over 10% palladium on carbon for 4 h under hydrogen atmosphere. The mixture was then filtered through Celite, washing with ethanol, and evaporated to dryness. The residue was purified by FCC, eluting with 0-10% MeOH in DCM, to give the title compound as a pale brown solid (154 mg, 86%). LCMS (Method 3): Rt 1.92 min, m/z 174.1 [MH−].

1. filtrationThe mixture was then filtered through Celite
2. washwashing with ethanol
3. customevaporated to dryness
4. customThe residue was purified by FCC
5. washeluting with 0-10% MeOH in DCM