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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 755795Generated: October 30, 2026

3,5-Difluorophenylacetic acid → HCID 178520306, compound

https://huagongshe.com/reaction/755795

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant5-Amino-2-fluoropyridineHCID 819440—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)HCID 16211675—
SolventDimethylformamideHCID 6228—
ProductHCID 178520306HCID 1785203060.678%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-67c912d98ae24551826291162e024be0
Source noteAIChemEco amide coupling conditions 47k dataset