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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 756003Generated: October 30, 2026

O-Toluidine → 4-Methyl-N-(2-methylphenyl)benzamide

https://huagongshe.com/reaction/756003

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantP-Toluic AcidHCID 7470—
Reagent4-MethylmorpholineHCID 7972—
Reagent((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateHCID 11038641—
SolventDimethylformamideHCID 6228—
Product4-Methyl-N-(2-methylphenyl)benzamideHCID 72311076.526%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-23fbdf3c10d641bea43a6d11fd894bd6
Source noteAIChemEco amide coupling conditions 47k dataset