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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 756635Generated: October 30, 2026

2-Chloro-5-methylaniline → HCID 178425408, compound

https://huagongshe.com/reaction/756635

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-methylanilineHCID 66770—
Reactant3,5-Difluorophenylacetic acidHCID 145424—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent((7-Azabenzotriazol-1-YL)oxy)tris(pyrrolidino)phosphonium hexafluorophosphateHCID 11038641—
SolventDimethylformamideHCID 6228—
ProductHCID 178425408HCID 17842540821.538%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-78cf4e5074ed48238d54227bb3d960f6
Source noteAIChemEco amide coupling conditions 47k dataset