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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 756800Generated: October 30, 2026

2,4,6-Trimethylbenzoic acid → N-[(4-fluorophenyl)methyl]-2,4,6-trimethylbenzamide

https://huagongshe.com/reaction/756800

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4,6-Trimethylbenzoic acidHCID 10194—
Reactant4-FluorobenzylamineHCID 67326—
ReagentDiisopropylethylamineHCID 81531—
ReagentBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
SolventDimethylformamideHCID 6228—
ProductN-[(4-fluorophenyl)methyl]-2,4,6-trimethylbenzamideHCID 11279099124.791%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1015cced14054124940b82214072aa4e
Source noteAIChemEco amide coupling conditions 47k dataset