HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum → Avibactam Sodium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum | HCID 5359268 | — |
| Reactant | Pyridinium, 4-(2-(((6R,7R)-2-carboxy-7-(((2Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)thio)-4-thiazolyl)-1-methyl-, inner salt | HCID 9852981 | — |
| Reactant | Chlorobutyl-isoprene | HCID 123522792 | — |
| Reactant | trans-7-Oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt | HCID 131731870 | — |
| Reactant | HCID 178418600 | HCID 178418600 | — |
| Product | Avibactam Sodium | HCID 24944097 | — |
Reaction Steps
Ceftaroline fosamil, trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt (Form I) and L-Arginine were blended in a twin shell blender (Patterson-Kelly) for times ranging from 15 to 60 minutes. The blend was subsequently weighed into vials and the vials were stoppered (with or without nitrogen), sealed and stored at different conditions to monitor stability. Packaging components used were 20 ml Type I glass vial, Gray chlorobutyl-isoprene stopper and Blue Aluminum tear-off seal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835455B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8a8361b9bf57490f9f9053e36ae83a81 |
| Source note | uspto-grants-2014_09 |