Water → HCID 178419968, compound

HRID 75685Notes

Reaction equation

HRID 75685 reaction equation
C(OC([N:8]1[C@H:13]([C:14]2[NH:15][CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]4[CH:30]=[CH:29][C:28]([C:31]5[N:32]=[C:33]([C@@H:36]6[CH2:44][CH:43]7[CH:38]([CH2:39][CH2:40][CH2:41][CH2:42]7)[N:37]6C(OC(C)(C)C)=O)[NH:34][CH:35]=5)=[CH:27][CH:26]=4)=[CH:21][CH:20]=3)[N:18]=2)[CH:12]2[CH2:52][CH:9]1[CH2:10][CH2:11]2)=O)(C)(C)C.O>CO>[CH:9]12[CH2:52][CH:12]([CH2:11][CH2:10]1)[C@@H:13]([C:14]1[NH:15][CH:16]=[C:17]([C:19]3[CH:20]=[CH:21][C:22]([C:25]4[CH:26]=[CH:27][C:28]([C:31]5[N:32]=[C:33]([C@@H:36]6[CH2:44][CH:43]7[CH:38]([CH2:39][CH2:40][CH2:41][CH2:42]7)[NH:37]6)[NH:34][CH:35]=5)=[CH:29][CH:30]=4)=[CH:23][CH:24]=3)[N:18]=1)[NH:8]2

Participants

4

Reactant 2

HCID 962WaterHCID 178451402HCID 178451402, compound

Product 1

HCID 178419968HCID 178419968, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

Compound 8 were taken in 9 ml methanol; 1 ml Conc. HCL and 0.2 ml water was added. Resulting reaction was stirred for 5 h at 50° C. (oil bath temp) completed, after completion of the reaction monitor by HPLC. The resulting slurry was cooled to RT and held with agitation for about 1H. Filtration of the slurry afforded a solid; washed with 15 ml acetone dried directly used in the next reaction.

Workup

  1. customResulting
  2. customreaction
  3. temperatureThe resulting slurry was cooled to RT
  4. filtrationFiltration of the slurry
  5. customafforded a solid
  6. washwashed with 15 ml acetone
  7. customdried directly
  8. customused in the next reaction

Sources & evidence

ORD record
ord-673eb56f20c2438095516ff5b6b1d4d6
Source dataset
uspto-grants-2014_09
Patent number
US08835456B1

Reaction notes

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