4-Methylbenzaldehyde → N-((1SR,4SR,7RS)-2-(4-methylbenzyl)-2-azabicyclo[2.2.1]heptan-7-yl)-1H-indazol-5-amine

HRID 75690Notes

Reaction equation

HRID 75690 reaction equation
[CH:1]12[CH:7]([NH:8][C:9]3[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=3)[N:14](C(=O)C(C)(C)C)[N:13]=[CH:12]4)[CH:4]([CH2:5][CH2:6]1)[CH2:3][NH:2]2.[CH3:24][C:25]1[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=1>>[CH3:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][N:2]2[CH2:3][CH:4]3[CH:7]([NH:8][C:9]4[CH:10]=[C:11]5[C:15](=[CH:16][CH:17]=4)[NH:14][N:13]=[CH:12]5)[CH:1]2[CH2:6][CH2:5]3)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 77254-MethylbenzaldehydeHCID 58306368HCID 58306368, compound

Product 1

HCID 53246936N-((1SR,4SR,7RS)-2-(4-methylbenzyl)-2-azabicyclo[2.2.1]heptan-7-yl)-1H-indazol-5-amine

Procedure

Reaction of Intermediate 14 with 4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-e03042e9c4594981a9c98bc76e8ade5d
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Reaction notes

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