4-Methylbenzaldehyde → 4-(4-(((1SR,4SR,7RS)-2-(4-methylbenzyl)-2-azabicyclo[2.2.1]heptan-7-yl)amino)phenyl)-1,2,5-oxadiazol-3-amine

HRID 75692Notes

Reaction equation

HRID 75692 reaction equation
[CH:1]12[CH:7]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([C:15]4[C:16]([NH2:20])=[N:17][O:18][N:19]=4)=[CH:11][CH:10]=3)[CH:4]([CH2:5][CH2:6]1)[CH2:3][NH:2]2.[CH3:21][C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1>>[CH3:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][N:2]2[CH2:3][CH:4]3[CH:7]([NH:8][C:9]4[CH:14]=[CH:13][C:12]([C:15]5[C:16]([NH2:20])=[N:17][O:18][N:19]=5)=[CH:11][CH:10]=4)[CH:1]2[CH2:6][CH2:5]3)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 77254-MethylbenzaldehydeHCID 672356774-(4-((1SR,4SR,7RS)-2-azabicyclo[2.2.1]heptan-7-ylamino)phenyl)-1,2,5-oxadiazol-3-amine

Product 1

HCID 532470544-(4-(((1SR,4SR,7RS)-2-(4-methylbenzyl)-2-azabicyclo[2.2.1]heptan-7-yl)amino)phenyl)-1,2,5-oxadiazol-3-amine

Procedure

Reaction of Intermediate 40 with 4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-1336a74b922d4f25b1e72fbf6a677702
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Reaction notes

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