HCID 67234356, compound → 2-(5-(((1SR,4SR,7SR)-7-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methyl)-2-methylphenoxy)ethanol

HRID 75694Notes

Reaction equation

HRID 75694 reaction equation
[CH:1]12[CH:7]([NH:8][C:9]3[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=3)[NH:14][N:13]=[CH:12]4)[CH:4]([CH2:5][CH2:6]1)[CH2:3][NH:2]2.[OH:18][CH2:19][CH2:20][O:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[CH3:30])[CH:25]=O>>[NH:14]1[C:15]2[C:11](=[CH:10][C:9]([NH:8][CH:7]3[CH:4]4[CH2:5][CH2:6][CH:1]3[N:2]([CH2:25][C:24]3[CH:27]=[CH:28][C:29]([CH3:30])=[C:22]([CH:23]=3)[O:21][CH2:20][CH2:19][OH:18])[CH2:3]4)=[CH:17][CH:16]=2)[CH:12]=[N:13]1

Participants

3

Reactant 2

HCID 67234356HCID 67234356, compoundHCID 866544283-(2-Hydroxyethoxy)-4-methylbenzaldehyde

Product 1

HCID 532470562-(5-(((1SR,4SR,7SR)-7-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methyl)-2-methylphenoxy)ethanol

Procedure

Reaction of Intermediate 23 with 3-(2-hydroxyethoxy)-4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-7a05c112722e49a2bf32401b4b571a5f
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Reaction notes

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