4-Methylbenzaldehyde → N-((1SR,2RS,4RS)-7-(4-methylbenzyl)-7-azabicyclo[2.2.1]heptan-2-yl)-1H-indazol-5-amine

HRID 75695Notes

Reaction equation

HRID 75695 reaction equation
[CH:1]12[NH:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[NH:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[CH:12]2.[CH3:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=1>>[CH3:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][N:7]2[CH:4]3[CH2:5][CH2:6][CH:1]2[CH:2]([NH:8][C:9]2[CH:10]=[C:11]4[C:15](=[CH:16][CH:17]=2)[NH:14][N:13]=[CH:12]4)[CH2:3]3)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 77254-MethylbenzaldehydeHCID 67234945N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)-1H-indazol-5-amine

Product 1

HCID 53247432N-((1SR,2RS,4RS)-7-(4-methylbenzyl)-7-azabicyclo[2.2.1]heptan-2-yl)-1H-indazol-5-amine

Procedure

Reaction of Intermediate 24 with 4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-284bc56e233840779d1dd5f5a4f7d0b8
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Reaction notes

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