4-Methylbenzaldehyde → HCID 53247550, compound

HRID 75698Notes

Reaction equation

HRID 75698 reaction equation
[CH:1]12[NH:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[NH:8][C:9]1[C:10]2[CH:11]=[CH:12][N:13]=[CH:14][C:15]=2[CH:16]=[CH:17][CH:18]=1.[CH3:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][CH:21]=1>>[CH3:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][N:7]2[CH:4]3[CH2:5][CH2:6][CH:1]2[CH:2]([NH:8][C:9]2[C:10]4[CH:11]=[CH:12][N:13]=[CH:14][C:15]=4[CH:16]=[CH:17][CH:18]=2)[CH2:3]3)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 77254-MethylbenzaldehydeHCID 67234592N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amine

Product 1

HCID 53247550HCID 53247550, compound

Procedure

Reaction of Intermediate 29 with 4-methylbenzaldehyde affords the title compound.

Sources & evidence

ORD record
ord-bb9ecf7bee554097a3121f005ebcafd2
Source dataset
uspto-grants-2014_09
Patent number
US08835457B2

Reaction notes

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