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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 75699Generated: October 25, 2026

N-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amine → 2-(5-(((1SR,2RS,4RS)-2-(isoquinolin-5-ylamino)-7-azabicyclo[2.2.1]heptan-7-yl)methyl)-2-methylphenoxy)ethanol

https://huagongshe.com/reaction/75699

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-((1SR,2RS,4RS)-7-azabicyclo[2.2.1]heptan-2-yl)isoquinolin-5-amineHCID 67234592—
Reactant3-(2-Hydroxyethoxy)-4-methylbenzaldehydeHCID 86654428—
Product2-(5-(((1SR,2RS,4RS)-2-(isoquinolin-5-ylamino)-7-azabicyclo[2.2.1]heptan-7-yl)methyl)-2-methylphenoxy)ethanolHCID 53247551—

Reaction Steps

Reaction of Intermediate 29 with 3-(2-hydroxyethoxy)-4-methylbenzaldehyde affords the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08835457B2
Source datasetuspto-grants-2014_09
ORD IDord-94d2a299b9f9413cb412910a9563dacc
Source noteuspto-grants-2014_09