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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 75703Generated: October 25, 2026

N-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amine → 2-(5-((4-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methyl)-2-methylphenoxy)ethanol

https://huagongshe.com/reaction/75703

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amineHCID 67234936—
Reactant3-(2-Hydroxyethoxy)-4-methylbenzaldehydeHCID 86654428—
Product2-(5-((4-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.2]octan-2-yl)methyl)-2-methylphenoxy)ethanolHCID 53245857—

Reaction Steps

Reaction of Intermediate 26 with 3-(2-hydroxyethoxy)-4-methylbenzaldehyde affords the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08835457B2
Source datasetuspto-grants-2014_09
ORD IDord-dece3dc160964cac8749447cd5effb01
Source noteuspto-grants-2014_09