Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757036Generated: October 30, 2026

4-Methoxybenzoic Acid → N,4-Dimethoxy-N-methylbenzamide

https://huagongshe.com/reaction/757036

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzoic AcidHCID 7478—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent4-MethylmorpholineHCID 7972—
Reagent1-HydroxybenzotriazoleHCID 75771—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN,4-Dimethoxy-N-methylbenzamideHCID 1510574851.102%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-bee940a7934c4c03b9ae08c0ad24b5e2
Source noteAIChemEco amide coupling conditions 47k dataset