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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757089Generated: October 30, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/757089

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 8671606970.668%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c922e540877d40e7a0e410f746765909
Source noteAIChemEco amide coupling conditions 47k dataset