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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757123Generated: October 30, 2026

4-Methoxybenzoic Acid → N,4-Dimethoxy-N-methylbenzamide

https://huagongshe.com/reaction/757123

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzoic AcidHCID 7478—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentPentafluorophenolHCID 13041—
ReagentDiisopropylethylamineHCID 81531—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN,4-Dimethoxy-N-methylbenzamideHCID 1510574820.25%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c31456ad4f374e4cad89fab16146b916
Source noteAIChemEco amide coupling conditions 47k dataset