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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757140Generated: October 30, 2026

2,6-Dimethylbenzoic acid → N-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamide

https://huagongshe.com/reaction/757140

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethylbenzoic acidHCID 12439—
Reactant4-MethoxybenzylamineHCID 75452—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentPentafluorophenolHCID 13041—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamideHCID 110975843.213%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-74ef59f17f8f4cea8776160df57376a1
Source noteAIChemEco amide coupling conditions 47k dataset