HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → trans-(4,5-Dihydro-5-(2-methoxypyridin-3-yl)oxazol-4-yl)(pyrrolidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Pyrrolidine, 1-(isocyanoacetyl)- | HCID 6455476 | — |
| Reactant | 2-Methoxypyridine-3-carbaldehyde | HCID 12533391 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | trans-(4,5-Dihydro-5-(2-methoxypyridin-3-yl)oxazol-4-yl)(pyrrolidin-1-yl)methanone | HCID 66901584 | 50% |
Reaction Steps
BAL 01014 was prepared in accordance with method D using 2-methoxy-3-pyridinecarboxaldehyde (0.64 ml, 5.43 mmol), KOH (0.305 mg, 5.43 mmol) in methanol (5 mL) and 2-isocyano-1-(pyrrolidin-1-yl)ethanone BLE 04098 (0.75 g, 5.43 mmol). After work-up trans-(4,5-dihydro-5-(2-methoxypyridin-3-yl)oxazol-4-yl)(pyrrolidin-1-yl)methanone BAL 01014 was obtained (0.74 mg, 50% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835463B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7eda041cba71432a8c31b17facd210dd |
| Source note | uspto-grants-2014_09 |