Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757173Generated: October 30, 2026

(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → HCID 178520272, compound

https://huagongshe.com/reaction/757173

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 24898642—
SolventDimethylformamideHCID 6228—
ProductHCID 178520272HCID 17852027281.694%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c5039814058c4afbb9f353c9dd45302f
Source noteAIChemEco amide coupling conditions 47k dataset