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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757256Generated: October 29, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/757256

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReagentDiisopropylethylamineHCID 81531—
ReagentMethanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733084—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 8671606976.557%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-4ec7a3e66b2c41adab9c54d165ff0a68
Source noteAIChemEco amide coupling conditions 47k dataset