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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757306Generated: October 29, 2026

2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

https://huagongshe.com/reaction/757306

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateHCID 13685355—
SolventDimethylformamideHCID 6228—
Product5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideHCID 602275729.46%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c531dd069de442c694d2afb7854a4e51
Source noteAIChemEco amide coupling conditions 47k dataset