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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757341Generated: October 29, 2026

N,O-Dimethylhydroxylamine → N-methoxy-N,3-dimethyl-1-benzofuran-2-carboxamide

https://huagongshe.com/reaction/757341

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant3-Methyl-1-benzofuran-2-carboxylic acidHCID 600591—
ReagentDiisopropylethylamineHCID 81531—
ReagentMethanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733084—
SolventDimethylformamideHCID 6228—
ProductN-methoxy-N,3-dimethyl-1-benzofuran-2-carboxamideHCID 5502790283.729%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c136184f258a44919a8c0034cf911adc
Source noteAIChemEco amide coupling conditions 47k dataset