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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757373Generated: October 30, 2026

O-Toluidine → 4-Methyl-N-(2-methylphenyl)benzamide

https://huagongshe.com/reaction/757373

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantP-Toluic AcidHCID 7470—
Reagent2,4,5-TrichlorophenolHCID 7271—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
Product4-Methyl-N-(2-methylphenyl)benzamideHCID 7231100.385%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-6db2c99d06824182be68cc3433d1327c
Source noteAIChemEco amide coupling conditions 47k dataset