Phosphorus oxychloride → 2-Cyclopentyl-7-(1,4-dimethylcyclohexyl)-5-ethylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

Participants

Reaction Steps

In analogy to the procedure for Example 1, 200 mg (0.55 mmol) crude N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]-1,4-dimethylcyclohexanecarboxamide, 165 mg (1.1 mmol) phosphoric trichloride are stirred at reflux for 4 hours, proportionate amounts of the solvents are used. The isomers are purified by chromatography (preparative HPLC).

Provenance & Evidence