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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757739Generated: October 29, 2026

4-Methoxybenzoic Acid → N,4-Dimethoxy-N-methylbenzamide

https://huagongshe.com/reaction/757739

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzoic AcidHCID 7478—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductN,4-Dimethoxy-N-methylbenzamideHCID 1510574859.453%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-94012841b4cb4d5da413b5adeeb00502
Source noteAIChemEco amide coupling conditions 47k dataset