HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → (S)-2-({3-[4-(6-Fluoro-benzothiazol-2-ylamino)-phenyl]-5-phenyl-isoxazole-4-carbonyl}-amino)-3-methoxy-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | methyl (2S)-2-amino-3-methoxypropanoate hydrochloride | HCID 13945137 | — |
| Reactant | HCID 86656488 | HCID 86656488 | — |
| Product | (S)-2-({3-[4-(6-Fluoro-benzothiazol-2-ylamino)-phenyl]-5-phenyl-isoxazole-4-carbonyl}-amino)-3-methoxy-propionic acid methyl ester | HCID 86656490 | 69% |
Reaction Steps
The title compound was prepared from 3-[4-(6-fluoro-benzothiazol-2-ylamino)-phenyl]-5-phenyl-isoxazole-4-carboxylic acid and (S)-2-amino-3-methoxy-propionic acid methyl ester hydrochloride as set forth in Example 5 and was obtained in 69% yield. Mass (ES+): 547 (M++1); IR (KBr): 3342, 3270, 1718, 1648, 1605, 1542; 1H NMR (DMSO-d6) δ: 3.23 (s, 3H), 3.61-3.68 (br, 5H), 4.79 (m, 1H), 7.16 (m, 1H), 7.53-7.58 (m, 4H), 7.80-7.87 (m, 7H), 9.53 (d, 1H), 10.73 (s, 1H, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835428B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-12cf83b1946841ef8e032c879770bac2 |
| Source note | uspto-grants-2014_09 |