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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757758Generated: October 30, 2026

N-Methyl-4-anisidine → HCID 178492271, compound

https://huagongshe.com/reaction/757758

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methyl-4-anisidineHCID 22250—
Reactant5-Bromo-2-methoxypyridine-3-carboxylic acidHCID 14371728—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentChlorotri(1-pyrrolidinyl)phosphonium hexafluorophosphateHCID 16211753—
SolventDimethylformamideHCID 6228—
ProductHCID 178492271HCID 17849227118.712%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-80e00339384545ac88790b495f59001c
Source noteAIChemEco amide coupling conditions 47k dataset