Potassium Bromide → 3-{4-[3-(4-Fluoro-phenyl)-ureido]-phenyl}-isoxazole-5-carboxylic acid

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Reaction Steps

The title compound was prepared from 3-{4-[3-(4-fluoro-phenyl)-ureido]-phenyl}-isoxazole-5-carboxylic acid ethyl ester using the procedure as set forth in Example 8 and was obtained in 95.2% yield. Mass (ES+): 342 (M++1); IR (KBr): 3307, 3004 (br), 2871 (br), 1711, 1640, 1601, 1546; 1H NMR (DMSO-d6) δ: 7.08 (t, 2H), 7.43 (m, 2H), 7.49 (d, 2H), 7.67 (s, 1H), 7.84 (d, 2H), 8.77 (s, 1H), 8.93 (s, 1H).

Provenance & Evidence