Leucine methyl ester hydrochloride → (S)-4-Methyl-2-({4-phenyl-3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carbonyl}-amino)-pentanoic acid methyl ester

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The title compound was prepared from 4-phenyl-3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid and (S)-2-amino-4-methyl-pentanoic acid methyl ester hydrochloride using the procedure as set forth in Example 5 and was obtained in 83% yield. Mass (ES−): 525 (M−−1); 1H NMR (DMSO-d6) δ: 0.75, 0.81 (2×d, 6H), 1.35-1.58 (m, 3H), 3.66 (s, 3H), 4.49 (m, 1H), 6.96 (t, 1H), 7.27 (t, 2H), 7.44 (d, 2H), 7.54 (m, 3H), 7.56 (d, 2H), 7.66 (d, 2H), 7.82 (m, 2H), 8.72 (br, 1H), 8.95 (br, 1H), 9.31 (d, 1H).

Provenance & Evidence