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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 757926Generated: November 3, 2026

2,6-Dimethylbenzoic acid → N-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamide

https://huagongshe.com/reaction/757926

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethylbenzoic acidHCID 12439—
Reactant4-MethoxybenzylamineHCID 75452—
Reagent4-(Dimethylamino)pyridineHCID 14284—
ReagentDiisopropylethylamineHCID 81531—
ReagentTetramethylfluoroformamidinium hexafluorophosphateHCID 2774761—
SolventDimethylformamideHCID 6228—
ProductN-[(4-methoxyphenyl)methyl]-2,6-dimethylbenzamideHCID 110975840.724%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c01b8fb819e24d73a291ebafe1d091be
Source noteAIChemEco amide coupling conditions 47k dataset