反应详情

The title compound was prepared from 3-{3-fluoro-4-[3-(4-fluoro-phenyl)-ureido]-phenyl}-isoxazole-5-carboxylic acid ethyl ester by using the procedure as described for the preparation of 3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid (Example 76, step 2) and was obtained in 89% yield; MS (m/z): 360 (M++1); 1H NMR (DMSO-d6) δ: 7.13 (t, 2H), 7.46 (m, 2H), 7.76 (m, 2H), 7.84 (m, 1H), 8.32 (t, 1H), 8.78, 9.18 (2×s, 2H, 2×NH).

1. customwas obtained in 89% yield