反应详情

The title compound was prepared using ethyl 3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl)isoxazole-5-carboxylate following the same procedure as described for preparation of the compound of step 7 of Example 98. The title compound was obtained as a white solid (91%) after drying in vacuo; 1H NMR (300 MHz, DMSO-d6) δ: 2.30 (s, 3H), 7.01-7.06 (m, 1H), 7.27-7.34 (m, 1H), 7.66 (S, 1H), 7.71-7.74 (d, J=8.7 Hz, 1H), 7.78 (s, 1H), 8.08-8.17 (m, 2H), 8.48 (s, 1H), 9.11 (s, 1H); IR (KBr) 3289, 3076, 2926, 1709, 1651, 1594, 1557, 1502, 1426, 1285, 1230, 1142, 1100, 964, 851 cm−1.

1. customThe title compound was prepared