Methyl 2-(3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl) isoxazole-5-carboxamido)-3-methylbutanoate → HCID 67354519, compound

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Reaction Steps

The title compound was prepared from methyl 2-(3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl)isoxazole-5-carboxamido)-3-methylbutanoate using the same procedure as described for preparation of the compound of step 9 of Example 98. The compound was obtained as an off-white solid after drying in vacuo. 1H NMR (300 MHz, DMSO-d6) δ: 0.86-0.88 (d, J=6.6 Hz, 6H), 2.12-2.18 (m, 1H), 2.33 (s, 3H), 3.95-3.99 (m, 1H), 7.00-7.05 (m, 1H), 7.25-7.33 (m, 1H), 7.62 (S, 1H), 7.68-7.71 (d, J=8.4 Hz, 1H), 7.76 (s, 1H), 7.99-8.11 (m, 3H), 8.89 (s, 1H), 9.45 (s, 1H); ms (ESI) m/z 473.2 [M+H]+.

Provenance & Evidence