2,4-Difluorophenyl isocyanate → Methyl 2-(3-(4-(3-(2,4-difluorophenyl)ureido)phenyl)isoxazole-5-carboxamido)-3-phenylpropanoate

Participants

Reaction Steps

The title compound was prepared according to the procedure as set forth in example 151, except that 2,4-difluoro-1-isocyanatobenzene was used in place of 1-fluoro-3-isocyanatobenzene and methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-phenylpropanoate was used in place of methyl 2-(3-(4-aminophenyl)isoxazole-5-carboxamido)-3-methylbutanoate to yield 62% of title compound. MS (ESI): m/z 521.2 (M+H)+; 1HNMR (DMSO-d6, 300 MHz) δ: 9.43(d, 1H), 9.28 (s, 1H), 8.58(s, 1H), 8.10 (m, 1H), 7.84 (d, 2H), 7.60 (d, 2H), 7.55 (s, 1H), 7.34 (m, 5H), 7.20 (m, 1H), 7.07 (m, 1H), 4.74 (m. 1H), 3.64 (s, 3H), 3.23 (m, 2H).

Provenance & Evidence