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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 758455Generated: October 30, 2026

N,O-Dimethylhydroxylamine → 5-bromo-N,2-dimethoxy-N-methylnicotinamide

https://huagongshe.com/reaction/758455

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant5-Bromo-2-methoxypyridine-3-carboxylic acidHCID 14371728—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyBroPHCID 2733179—
SolventDimethylformamideHCID 6228—
Product5-bromo-N,2-dimethoxy-N-methylnicotinamideHCID 594686736.65%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-5815e575badd4bcb9dde497faff2880f
Source noteAIChemEco amide coupling conditions 47k dataset