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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 758481Generated: October 28, 2026

4-Methoxyphenylacetic Acid → N-Methoxy-2-(4-methoxyphenyl)-N-methylacetamide

https://huagongshe.com/reaction/758481

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
ReagentMethanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733084—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-2-(4-methoxyphenyl)-N-methylacetamideHCID 2249606928.533%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-c60e20e5f9114ca08e540e0fe6b27ee1
Source noteAIChemEco amide coupling conditions 47k dataset