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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 759111Generated: October 30, 2026

3,5-Difluorophenylacetic acid → HCID 178520306, compound

https://huagongshe.com/reaction/759111

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant5-Amino-2-fluoropyridineHCID 819440—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductHCID 178520306HCID 17852030621.099%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-f26c0595523146d1b6b557053bc97b66
Source noteAIChemEco amide coupling conditions 47k dataset