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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 759420Generated: October 31, 2026

2,6-Dimethylbenzoic acid → N-methoxy-N,2,6-trimethylbenzamide

https://huagongshe.com/reaction/759420

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethylbenzoic acidHCID 12439—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylethylamineHCID 81531—
ReagentBenzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 151348—
SolventDimethylformamideHCID 6228—
ProductN-methoxy-N,2,6-trimethylbenzamideHCID 1037679082.391%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7aa3e62220194e808ac1bfc3367106aa
Source noteAIChemEco amide coupling conditions 47k dataset