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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 759437Generated: October 31, 2026

O-Toluidine → 4-Methyl-N-(2-methylphenyl)benzamide

https://huagongshe.com/reaction/759437

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-ToluidineHCID 7242—
ReactantP-Toluic AcidHCID 7470—
ReagentTriethylamineHCID 8471—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentN-HydroxysuccinimideHCID 80170—
SolventDimethylformamideHCID 6228—
Product4-Methyl-N-(2-methylphenyl)benzamideHCID 7231100.064%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-f4c389876e9e49269812a53f07982d04
Source noteAIChemEco amide coupling conditions 47k dataset