反应详情

To a solution of Methyl 3-(benzyloxy)-5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]benzoate (28 g) (Intermediate 8) in glacial acetic acid, suspension of 10% Pd/C in glacial acetic acid was added in Parr hydrogenation apparatus. The reaction was subjected under 60 PSI of hydrogen for 6 h. After completion, the reaction mixture was filtered to remove catalyst. Filtrate was poured into ice, the solid obtained was filtered, washed with water, saturated sodium bicarbonate solution, water, petroleum ether, air dried to obtain desired product (18 g, 70%).

1. additionwas added in Parr hydrogenation apparatus
2. filtrationAfter completion, the reaction mixture was filtered
3. customto remove catalyst
4. additionFiltrate was poured into ice
5. customthe solid obtained
6. filtrationwas filtered
7. washwashed with water, saturated sodium bicarbonate solution, water, petroleum ether, air
8. customdried