反应详情

To a stirring solution of Methyl 3-(benzyloxy)-5-(4-formylphenoxy)benzoate (30 g) (Intermediate 11) in acetone, Jones reagent was added drop wise at 0° C. until the brown color persists in the reaction mixture. After completion of the reaction mixture was diluted with water and extracted with DCM. All organic layers were combined and washed with water, brine, dried over anhydrous sodium sulphate, filtered and concentrated under vacuum to get pure white solid (30 g).

1. extractionextracted with DCM
2. washwashed with water, brine
3. dry with materialdried over anhydrous sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated under vacuum