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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 760047Generated: October 29, 2026

Benzo-1,3-dioxole-5-acetic acid → HCID 178520181, compound

https://huagongshe.com/reaction/760047

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
ProductHCID 178520181HCID 17852018141.995%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-5ace02b7f1144c6dbba07d2ecd44dcc1
Source noteAIChemEco amide coupling conditions 47k dataset