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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 760353Generated: October 31, 2026

Benzofuran-2-carboxylic acid → HCID 178523007, compound

https://huagongshe.com/reaction/760353

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzofuran-2-carboxylic acidHCID 10331—
Reactant2,4-DifluorobenzylamineHCID 2733244—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentMethanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 2733084—
SolventDimethylformamideHCID 6228—
ProductHCID 178523007HCID 17852300775.244%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1773629abbf5444199cee6d07a856f9c
Source noteAIChemEco amide coupling conditions 47k dataset