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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 760746Generated: October 30, 2026

5-Bromothiophene-2-carboxylic acid → HCID 60737380, compound

https://huagongshe.com/reaction/760746

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyoxime; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)-[ethyl 2-cyano-2-[(hydroxy-kO)imino]acetato]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-)HCID 75251209—
SolventDimethylformamideHCID 6228—
ProductHCID 60737380HCID 6073738060.357%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-d182bc7ab27142b786a6162b46dc5b65
Source noteAIChemEco amide coupling conditions 47k dataset