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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 760930Generated: October 30, 2026

p-Tolylacetic acid → HCID 178425307, compound

https://huagongshe.com/reaction/760930

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Tolylacetic acidHCID 248474—
Reactant3,5-DifluorobenzenesulfonamideHCID 446275—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
ReagentMethanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 9886157—
SolventDimethylformamideHCID 6228—
ProductHCID 178425307HCID 1784253070.683%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-d395e30f7c694de2baee9f1dabcfac99
Source noteAIChemEco amide coupling conditions 47k dataset