化工社化工社 化学情報印刷レポート · 研究参考用
6-Ethyl-3,5-dimethoxy-pyridine-2-carboxylic acid hydrazide → N[6-ethyl-3,5-dimethoxy-pyridine-2-carboxamidyl]-N'-(1-Methyl-1H-indol-5-yl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Ethyl-3,5-dimethoxy-pyridine-2-carboxylic acid hydrazide | HCID 66986619 | — |
| 反応物 | 5-isothiocyanato-1-methyl-1H-indole | HCID 86621682 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N[6-ethyl-3,5-dimethoxy-pyridine-2-carboxamidyl]-N'-(1-Methyl-1H-indol-5-yl)-thiourea | HCID 86621683 | 73.3% |
反応手順
A flask was charged with 6-ethyl-3,5-dimethoxy-pyridine-2-carboxylic acid hydrazide (34 mg; 0.15 mmol), 5-isothiocyanato-1-methyl-1H-indole (28 mg; 0.15 mmol) and ethanol (2 mL) and the mixture was heated at reflux for three hours. The reaction was then cooled, and the precipitate was filtered and dried to give N-[6-Ethyl-3,5-dimethoxy-pyridine-2-carboxamidyl]-N′-(1-Methyl-1H-indol-5-yl)-thiourea (44 mg; 0.11 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835464B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c1136b2b83144bfa95d1c2198c209054 |
| 出典メモ | uspto-grants-2014_09 |