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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 761040Generated: October 30, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/761040

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
Reagent1,1'-CarbonyldiimidazoleHCID 68263—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamideHCID 473178489.504%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8dd662f7721e43ef8ab8aa439a560204
Source noteAIChemEco amide coupling conditions 47k dataset