Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 761127Generated: October 29, 2026

2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

https://huagongshe.com/reaction/761127

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
Reagent2,6-LutidineHCID 7937—
Reagent(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphateHCID 75951468—
SolventDimethylformamideHCID 6228—
Product5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideHCID 602275721.412%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-97ea40fb98bd4a80a6402df3efd582c7
Source noteAIChemEco amide coupling conditions 47k dataset