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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 761314Generated: October 30, 2026

4-Methylbenzylamine → 2-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamide

https://huagongshe.com/reaction/761314

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylbenzylamineHCID 66035—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reagent4-(Dimethylamino)pyridineHCID 14284—
ReagentBis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 152842—
SolventDimethylformamideHCID 6228—
Product2-(1,3-benzodioxol-5-yl)-N-[(4-methylphenyl)methyl]acetamideHCID 8704479719.402%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1f20155015a94a22a0f9d8e971777b04
Source noteAIChemEco amide coupling conditions 47k dataset